The network for harvesting and transplantation of organs and tissues was formally constituted with Italian Law 91/99. The law specifies how all the operations connected with this complex system are to be managed and coordinated. Organisation is national and involves:
The National Transplantation Centre (NTC) – the technical centre reporting to the Ministry for Health in charge of tissue harvesting and processing procedures as well as the distribution network.
The Standing Transplantation Committee governing the technical and operational activities involved in the harvesting and transplantation of organs and tissues, an advisory body of the National Transplantation Centre.
The Inter-regional and Regional Transplantation Centres (ORTC and RTC) – bodies mandated by the National Transplantation Centre to monitor and ensure the quality and safety of donor tissues, and coordinate the 24/7 service.
Regional Hospital Coordination System (RHCS) – involving healthcare management staff of the hospital facilities ensuring the organisation and governance of all the phases preceding harvesting, i.e. proposing donation and relations with donors' families.
All phases of the process are recorded on the Transplantation Information System (TIS), which guarantees safety, traceability and transparency.